Listar por autor "Centeno, Alberto"
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A MicroRNA transcription factor blueprint for early atrial arrhytmogenic remodeling
Torrado, Mario; Franco, Diego; Lozano-Belasco, Estefanía; Hernández-Torres, Francisco; Calviño-Santos, Ramón; Aldama López, Guillermo; Centeno, Alberto; Castro-Beiras, Alfonso; Mikhailov, Alexander T. (Hindawi, 2015)[Abstract] Spontaneous self-terminating atrial fibrillation (AF) is one of the most common heart rhythm disorders, yet the regulatory molecular mechanisms underlying this syndrome are rather unclear. MicroRNA (miRNA) ... -
Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro
Torrado, Mario; Iglesias Reinoso, Raquel; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (SAPE / Society for Experimental Biology and Medicine, 2010)[Abstract] Brain natriuretic peptide/natriuretic peptide precursor B (NPPB) is one of the most studied genes in relation to heart failure (HF) conditions. However, it is still unclear as to whether alternative splicing ... -
In vivo forced expression of myocardin in ventricular myocardium transiently impairs systolic performance in early neonatal pig heart
Torrado, Mario; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (UPV/EHU Press, 2008-01-30)[Abstract] The aim of this study was to determine the effects of forced expression of myocd-A in the left ventricular (LV) myocardium on cardiac performance in early neonatal piglets. LV transfection with the gene for ... -
Intraneural IFG-1 in cryopreserved nerve isografts increase neural regeneration and functional recovery in the rat sciatic nerve
González Porto, Sara Alicia; Doménech, Nieves; Blanco García, Francisco J; Centeno, Alberto; Rivadulla, Casto; Álvarez Jorge, Álvaro; Sánchez Ibáñez, Jacinto; Rendal Vázquez, María Esther (Oxford, 2018-07-27)[Abstract] Background: Insulin-like growth factor 1 (IGF-1) was found to stimulate Schwann cell mitosis. Exogenous IGF-1 may improve nerve regeneration after cryopreservation. Objective: To evaulate the effect of ... -
Intron retention generates ANKRD1 splice variants that are co-regulated with the main transcript in normal and failing myocardium
Torrado, Mario; Iglesias, Raquel; Nespereira, Beatriz; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (Elsevier, 2009-03-31)[Abstract] The cardiac ankyrin repeat domain 1 protein (ANKRD1, also known as CARP) has been extensively characterized with regard to its proposed functions as a cardio-enriched transcriptional co-factor and stress-inducible ... -
Mitochondrial DNA Impact on Joint Damaged Process in a Conplastic Mouse Model After Being Surgically Induced With Osteoarthritis
Scotece, Morena; Rego-Pérez, Ignacio; Lechuga-Vieco, Ana Victoria; Centeno, Alberto; Jiménez-Gómez, María Concepción; Filgueira-Fernández, P.; Vaamonde-García, Carlos; Enríquez, José Antonio; Blanco García, Francisco J (Nature, 2021-04-27)[Abstract] It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced ... -
Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart
Torrado, Mario; Iglesias Reinoso, Raquel; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (PLoS, 2011)[Abstract] Background. Myocardin (MYOCD), a potent transcriptional coactivator of smooth muscle (SM) and cardiac genes, is upregulated in failing myocardium in animal models and human end-stage heart failure (HF). However, ... -
The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint
Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-06)[Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ... -
The use of antidotes for calcium gluconate extravasation: an experimental study in mice
Pacheco Compaña, Francisco Javier; Midón Míguez, José; De-Toro, Javier; Centeno, Alberto; López San Martín, Patricia; Yebra-Pimentel Vidal, María Teresa; Mosquera Osés, Joaquín José (Wolters Kluwer, 2018)[Abstract] Background: Calcium gluconate extravasation is a process that can cause serious lesions, such as necrosis and calcification of the soft tissues. The aim of the present study was to analyze the beneficial effects ...